Mpox Vaccine

Available to any person who wants protection from mpox infection.

Mpox Vaccine

SF vaccine sites are now providing the second dose of the mpox (Jynneos) vaccine to people who are at least 28 days from receiving their first dose.

Mpox Vaccine Administration

SFDPH & partner sites offer first and second doses of the mpox vaccine though subcutaneous injection for eligible people who prefer this method over an intradermal injection. Both methods provide the same amount of protection against mpox. Click here to learn more about both methods. No matter the choice you make, it is important to get your second dose of the mpox vaccine if it has been at least 28 days since you received your first dose, to be fully vaccinated against mpox. 


Anyone who wants protection from mpox infection may receive the mpox vaccine

There is no shortage of mpox vaccine now, and so the San Francisco Department of Public Health (SFDPH) and many other health departments in California have removed all the eligibility criteria.  Anyone who may be at risk of getting mpox can now receive the JYNNEOS vaccine to prevent mpox. There is no need to prove eligibility for the vaccine.  

Some people are still at higher risk of getting mpox than others, and those persons are now considered priority groups that are recommended to get the JYNNEOS vaccine.

SFDPH recommends mpox vaccination with JYNNEOS for these priority groups:  

  • Persons who have had a known exposure to mpox and need post-exposure prophylaxis (PEP)
  • People with occupational (job-related) risk, including
    • Healthcare workers likely to collect laboratory specimens from patients with mpox
    • Persons working in sexual health clinics
    • Persons working in clinical settings that serve at-risk populations
    • Any occupational group recommended by Advisory Committee on Immunization Practices (ACIP) to get the vaccine
  • Any person living with HIV, especially those with risk of complications of mpox, such as persons with a CD4 count <350/mm3, an unsuppressed viral load, or who have had an opportunistic infection
  • Any man, trans person, or nonbinary person who has sex with men, trans persons, or nonbinary persons
  • Persons who are taking or are eligible to take HIV PrEP
  • Sex workers
  • Sexual contacts of any persons included above
  • Persons who have had close contact, within the past 6 months, with someone with suspected or confirmed mpox
  • Persons who had sex or close contact, within the past 6 months, at a venue or event, or within a social group, with a suspected or confirmed mpox case. This includes persons who received notice from a venue or event of a potential exposure.
  • Persons diagnosed, in the past 3 months, with a bacterial sexually transmitted disease (for example: chlamydia, gonorrhea, syphilis)
  • Persons who expect to experience any of the above

Two doses of JYNNEOS should be received, with at least 4 weeks separation between doses. This helps ensure longer-term protection against mpox.

If it has been more than 4 weeks since the first dose, the second dose can be administered as soon as possible, and the series does not need to be restarted.

If you have received your second dose, there is no need for a third dose at this time.

Since no vaccine is 100 percent effective, it is important for individuals to reduce the risk of potential exposures to mpox both before and after vaccination. Learn more about mpox infections after vaccination.

Mpox Vaccine Sites

Many medical clinics and primary care practices in San Francisco offer Jynneos vaccine. Contact your health care provider to schedule a Jynneos vaccine appointment. If you do not have a regular health care provider or clinic that you visit, you can still get vaccinated.

You can make an appointment at one of our neighborhood sites by clicking here.

You can also find the vaccine using the CDC's vaccine locator here.

The following locations have supplies of Jynneos vaccine by appointment only:    

  • Adult Immunization and Travel Clinic (AITC) patients: please make an online appointment at

  • SF City Clinic: call 628-217-6600

  • San Francisco AIDS Foundation, Clinic at Strut: 415-581-1600 

  • Kaiser Permanente patients and non-patients: call 415-238-3880

How to get proof of Mpox vaccination


  • Check your medical record or ask your provider

    You can find it in your online health record under the immunization history section. If you don’t see it, ask your healthcare provider.  Your provider should have a record of vaccination dates and locations. They can also print your immunization record through the California Immunization Registry (CAIR)
  • Request a record from CAIR

    CAIR was not designed for a high volume of requests. Use this method if the above options are not possible. Requests may take up to 14 business days, so please plan ahead. The California Immunization Registry (CAIR) is a secure immunization information system for California. Fill out this form to get your record emailed to you. Travelers from outside the U.S. who get vaccinated in California may email the Help Desk to get the form. Residents of Alpine, Amador, Calaveras, Mariposa, Merced, San Joaquin, Stanislaus, and Tuolumne counties: Visit My Healthy Futures to get your immunization record.
Last updated August 30, 2023